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Blood Types and Pregnancy Question

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Okay hopefully there is a medical or science whiz out there that can answer this for me!

I know that it's genetically impossible for a mother with type O blood to have a child with type AB blood. But is it biologically possible for her to carry one? (Like say as a surrogate.) Would there be any issue beyond rh factor incompatibility?
#1 - July 29, 2010, 05:09 PM
« Last Edit: July 29, 2010, 05:16 PM by valeriek »
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From Wikipedia:

Many pregnant women carry a fetus with a different blood type from their own, and the mother can form antibodies against fetal RBCs. Sometimes these maternal antibodies are IgG, a small immunoglobulin, which can cross the placenta and cause hemolysis of fetal RBCs, which in turn can lead to hemolytic disease of the newborn, an illness of low fetal blood counts that ranges from mild to severe.[3]



From me:
Also, if the male culprit has AB Blood wouldn't it be possible for the embryo/fetus to claim that? Or would his contribution be A only or B only.

(Curious minds want to know.)

Fascinating question BTW. B

#2 - July 30, 2010, 03:34 AM
« Last Edit: July 30, 2010, 06:02 AM by AE »
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Thanks. The bit from wikipedia is part of the incompatibility I was referring to. I just wasn't sure if it extended to AB in an O mother.  To answer your question about an AB father and an O mother making an AB baby, from my research, no. AB babies are born only when one parent is AB and the other is A or B, or one parent is A and the other B. (If you're interested, there's a genetic chart I found here: http://www.classkids.org/library/classqa/bloodtyp.htm)

I think I did find the answer to my question last night.  Which is that yes, a type O mother can carry a type AB baby without a problem.

From this website:

It turns out that most anti-A or anti-B antibodies are of the IgM class and these do not cross the placenta. In fact, an Rh−/type O mother carrying an Rh+/type A, B, or AB  fetus is resistant to sensitization to the Rh antigen. Presumably her anti-A and anti-B antibodies destroy any fetal cells that enter her blood before they can elicit anti-Rh antibodies in her.

They don't mention that her anti-A and anti-B antibodies themselves would be an issue in carrying the child, which makes sense since she can create and carry type A and B babies. So, yeah, I guess I wasted everyone's time with this thread! Thanks for helping me!
#3 - July 30, 2010, 06:18 AM
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heartsandflowers

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Hi....

I am O- and have the RH factor too. I have my son whom is now 7 years old who is B+. Yet I did have two shots since I do have the RH factor. I had a normal birth and everything was fine, except since I am so hyper active I went into labor early (one month). So you can have a heathy baby with one set of parents from two different blood types. My husband is AB+ so it worked out ok... If you have any other questions I would be more then happy to help. On the other hand I also have a daughter and she is 0- like me so I only needed one shot that is also with my husband whom is AB+. So it all worked out great in the end!!! :hearts
#4 - July 30, 2010, 11:05 AM

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I don't know my blood type. I've asked to have it tested, just to know, and they told me it wasn't important because they'd test it if they ever needed to know. How do other people come to learn theirs?
#5 - July 30, 2010, 12:05 PM

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Thanks heartsandflowers! That's good to know!

Kurtis - I learned my blood type first from my mother, who knew because they doctor told her because of the rh factor (I'm + she's -) and then again when I registered to be a bone marrow donor. I think they'll also tell you if you ever donate blood. I know I have a donor card from the Red Cross that says my type on it and I believe they sent it to me after I gave at a blood drive.
#6 - July 30, 2010, 12:12 PM
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Kurtis

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I'm not allowed to give blood because I lived in Africa in the 1980s.
#7 - July 30, 2010, 01:20 PM

I was going to mention the Rh shots.

I can't give blood either, Kurtis. My granny died of Creutzfeldt-Jakob disease. (mad cow in humans)
http://www.ninds.nih.gov/disorders/cjd/detail_cjd.htm
#8 - July 30, 2010, 02:37 PM
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I'm Rh- and have had shots until recently when my husband began donating blood. We'd thought for years he was B+, but turns out he's B-. No more shots for me! (I'm due in Sept.) But I am very grateful for the technology and knowledge, for my daughters' sakes.
#9 - July 30, 2010, 09:03 PM

ecb

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I don't know my blood type. I've asked to have it tested, just to know, and they told me it wasn't important because they'd test it if they ever needed to know. How do other people come to learn theirs?

I've gotten this, as well!  In fact, I almost had a blood transfusion last year, and they still wouldn't tell me (and they clearly knew, b/c they were getting ready to get more of it!). I don't know why it's such a big secret.

I'm A+, btw. My mama told me. :moose She remembered from my birth. It caused big laughs here at home because my DH is B... and I *always* got better grades when we took classes together. :dr  He was affronted.
#10 - July 31, 2010, 06:22 PM

Kurtis,
You can order blood typing kits online. We did this for our homeschooled daughter's anatomy class this year.

ecb: I'm confused as to why they won't tell you. It's good to know in an emergency (or pregnancy!) Where do you live?
#11 - July 31, 2010, 07:14 PM

If you ever donate blood they'll tell you your blood type. I first found out mine (A-) when I was pregnant because I had to have the shots since my husband's positive.
I don't understand why they wouldn't tell you your blood type--it's definitely important info to have in an emergency (Red Cross gives you a donor card that lists it, I believe... not sure where mine is right now.)
#12 - July 31, 2010, 07:18 PM

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I'm A+ (don't remember if I found out through donating blood or what,) and our daughter is A-.  She was tested at birth, because she was so big,esp for a first baby. (8# 15 oz)  Oddly, they didn't bother to test either of her brothers, who were 9# 14oz and 10#10oz.

When the obgyn asked if I were going for 11#, I said NO!

anita
#13 - July 31, 2010, 07:32 PM

We typed our blood in college biology class. I'm O+ -- which wasn't a huge shock since my mother was O- and my father was O+
It left limited options for all of us kids.
#14 - August 01, 2010, 06:23 AM
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Kurtis

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Kurtis,
You can order blood typing kits online. We did this for our homeschooled daughter's anatomy class this year.

ecb: I'm confused as to why they won't tell you. It's good to know in an emergency (or pregnancy!) Where do you live?

Minnesota. That was exactly what I said and they said they always test/verify blood before giving a transfusion anyway. Apparently blood types can even change, although it's rare. I just wondered if I was the only one who didn't know. Most people seem to.
#15 - August 01, 2010, 04:01 PM

Kurtis

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If you ever donate blood they'll tell you your blood type.

I'm prevented from donating blood because I lived in Africa in the 1980s. I've waited in line just to have them turn me down.
#16 - August 01, 2010, 04:08 PM

Valeriek,

Here's the answer to your question. An O type mom can carried an AB child, BUT then she wouldn't be the biological mom to that AB child. An AB child has received an A from one parent and a B from another parent. Remember those Punnett squares we had to do in high school biology. If you cross a mom who is O with an AB dad, there children would be either an A or a B, taking  one of the father's trait. The O mom of an AB child would have to be a surrogate. AB is a blood type, but it is not an allele. So the dad can't donate both to the child. He received both allele from his parents, but he can't pass it on that way. But let say we're talking alien conception....
#17 - August 03, 2010, 06:24 AM
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mlBrown, Congraulation!! Your first? :flowers2
#18 - August 03, 2010, 06:33 AM
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Thanks, Shellie! Not my first. My tenth! :)
#19 - August 03, 2010, 06:38 AM

LOL, Now I remember you posting that last year. Much respect. :bow
#20 - August 03, 2010, 06:55 AM
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I know that it's genetically impossible for a mother with type O blood to have a child with type AB blood. But is it biologically possible for her to carry one? (Like say as a surrogate.) Would there be any issue beyond rh factor incompatibility?

By the way, it's not genetically impossible, just very unlikely.

Quote
There are cases where someone can appear O when they are actually A, B, or AB genetically. And there are some cases where an AB child can actually be A or B genetically. In both cases, an O parent can have an AB child.

http://www.thetech.org/genetics/ask.php?id=115
#21 - August 23, 2010, 10:35 PM
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I know this is a relatively old thread but I wanted to add my two cents about knowing your blood type.  It is your RIGHT to know what blood type you are. If you ask your primary doctor to add blood type to any routine blood draw they should respect your wishes.  It's your body, you want to know your blood type, it shouldn't be a mystery and they shouldn't keep it from you if they already know! I'm outraged that those of you who said they wouldn't tell you your blood type or test for it!
#22 - August 24, 2010, 06:59 AM
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